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                  案例分享

                  精神分裂患者PBMC中糖代謝嚴重紊亂的目標代謝物研究

                  發布日期:2019.08.23

                  文獻中實驗基于氣相色譜-質譜聯用設備作為儀器平臺,代謝組學技術為主要手段來研究精神分裂患者外周血單核細胞(PBMC)中糖代謝嚴重紊亂的代謝特征。包括以下圖中的物質在內,整個糖代謝糖酵解通路的物質,以及論文中涉及的實驗分析技術方法我公司現已對外提供服務。

                   

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                  文獻內容

                  Title:Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study.

                  Author:Liu ML , Zhang XT , Du XY , Fang Z , Liu Z , Xu Y , Zheng P , Xu XJ , Cheng PF , Huang T , Bai SJ , Zhao LB , Qi ZG , Shao WH , Xie P .

                  Journal: J Transl Med

                  Keywords: cancer、cancer diagnosis、diagnostic biomarkers、lipidomics、liquid chromatogr-aphy-mass spectrometry、NMR spectroscopy、prognostic biomarkers、untargeted metabolon-mics targeted metabolomics.

                  Abstract:
                  Schizophrenia is a widespread and debilitating mental disorder. However, the underlying molecular mechanism of schizophrenia remains largely unknown and no objective laboratory tests are available to diagnose this disorder. The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for schizophrenia. Gas chromatography/mass spectrometry based targeted metabolomic method was used to quantify the levels of 13 glucose metabolites in peripheral blood mononuclear cells (PBMCs) derived from healthy controls, schizophrenia and major depression subjects (n = 55 for each group). The majority (84.6%) of glucose metabolites were significantly disturbed in schizophrenia subjects, while only two (15.4%) glucose metabolites were differently expressed in depression subjects relative to healthy controls in both training set (n = 35/group) and test set (n = 20/group). Antipsychotics had only a subtle effect on glucose metabolism pathway. Moreover, ribose 5-phosphate in PBMCs showed a high diagnostic performance for first-episode drug-na&iuml;ve schizophrenia subjects. These findings suggested disturbance of glucose metabolism may be implicated in onset of schizophrenia and could aid in development of diagnostic tool for this disorder.

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