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                  譜領新聞

                  Nature Medicine期刊在線發表了譜領客戶所屬寧光院士團隊的論文

                  發布日期:2018.02.09

                  熱烈祝賀頂級期刊Nature Medicine于2017年6月19日在線發表了我公司客戶所屬的寧光院士團隊以Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention為名的論文!譜領生物為其提供了血清代謝組學核心部分的實驗和數據分析服務。

                  本篇論文系統性研究分析了肥胖、干預治療減肥個體間的腸道菌群和血清代謝組學。
                  您可以通過掃描下方微信二維碼關注譜領代謝組學平臺回復“腸道菌群”或“最新論文”獲取本論文詳細解讀。
                  以下是本文基本情況:
                  Title:Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention;

                  Author:Ruixin Liu1,16, Jie Hong1,16, Xiaoqiang Xu2,3,16, Qiang Feng2,4,16, Dongya Zhang2,16, Yanyun Gu1,16, Juan Shi1, Shaoqian Zhao1, Wen Liu1, Xiaokai Wang2,3 , Huihua Xia2,5, Zhipeng Liu2, Bin Cui1,6, Peiwen Liang1, Liuqing Xi1, Jiabin Jin7, Xiayang Ying7, Xiaolin Wang8, Xinjie Zhao8, Wanyu Li1, Huijue Jia2,5,9 , Zhou Lan2, Fengyu Li2, Rui Wang1, Yingkai Sun1, Minglan Yang1, Yuxin Shen1, Zhuye Jie2,5, Junhua Li2,5,9, Xiaomin Chen2, Huanzi Zhong2,5 , Hailiang Xie2, Yifei Zhang1, Weiqiong Gu1 , Xiaxing Deng7, Baiyong Shen7, Xun Xu2,5, Huanming Yang2,10, Guowang Xu8 , Yufang Bi1, Shenghan Lai11, Jian Wang2,10, Lu Qi12,13, Lise Madsen2,14,15, Jiqiu Wang1, Guang Ning1,6, Karsten Kristiansen2,5,15 & Weiqing Wang1

                  Journal:Nature Medicine(IF=29.89);published online 19 June 2017; doi:10.1038/nm.4358;
                  Abstract:

                  Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate- fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

                  以下本文精彩圖文:

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